![]() ![]() In this review, we analyze the benefits and risks of chromium compounds on male fertility, as well as the mechanisms underlying (in)fertility outcomes. Data from the literature pinpoints mechanisms of oxidative stress induced by chromium compounds in somatic and germ cells that lead to apoptosis, thus underlining the impairment of fertility potential. However, workers worldwide are still exposed to hexavalent chromium, particularly in electronics and military industries. ![]() Previous studies have demonstrated severe lesions to mouse spermatogenesis after exposure to chromium (VI). ![]() Chromium (VI) is known for its deleterious effects on male reproductive health as toxic, carcinogenic, and mutagenic. On the other hand, chromium (VI) compounds are widely used in several industries, despite being well-known environmental pollutants (i.e., welding fumes). Comprehensive studies on the role of this compound will help to establish the safe and useful use of chromium supplementation. Furthermore, the long-term effects of chromium picolinate on the antioxidant system of treated subjects have not been properly studied. Contradictory results are documented in the literature and deserve discussion. However, previous studies showed that animal models exposed to chromium picolinate experienced degenerative changes in spermatogenesis. Chromium (III) compounds, i.e., Cr(III)-tris-picolinate,, known as chromium picolinate, are used as nutritional supplements for the control of diabetes, body weight, and muscular growth. Chromium compounds are widely used in the +3 and +6 valence states, as food supplements, and in the industrial field, respectively. In general, male reproductive health is highly sensitive to oxidative stress, which results in reversible and/or irreversible changes in testosterone-producing cells, spermatogenesis, and sperm quality. Male reproductive tissues are strongly susceptible to several environmental and lifestyle stressors. ![]()
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